Master of Science (MS)
First Committee Member
Stephen W. Carper
Number of Pages
Cancer occurs when normal cells fail to die in response to various cell death signals. Normal eukaryotic cells exhibit two major forms of cell death--Necrosis and Apoptosis. Apoptosis can be triggered in cells by various agents. Studies have shown that an elevated amount of Hsp 27 protects cells from apoptosis induced by Sodium Butyrate. In this study, we treated estrogen receptor negative human breast cancer cells with apoptotic inducers such as Sodium Butyrate, Staurosporine, Vitamin E Succinate and Cycloheximide. The cells that constitutively expressed Hsp 27 had a higher growth in the presence of Cycloheximide and Vitamin E Succinate and also exhibited lesser apoptosis in the presence of Sodium Butyrate and Staurosporine. This study demonstrates that Hsp 27 blocks cell death in breast cancer cells in the presence of certain cytotoxic drugs and the presence of this protein could serve as a marker for aggressive tumors.
Apoptosis; Breast; Cancer; Cells; Heat; Human; Inhibition; Protein; Shock
Biochemistry; Cellular biology; Oncology
University of Nevada, Las Vegas
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Padmanabhan, Sindhu, "Heat shock protein 27 inhibition of apoptosis in human breast cancer cells" (1998). UNLV Retrospective Theses & Dissertations. 939.
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