Title

Randomized Double-Blinded Comparison of Titrated Oral Versus Vaginal Misoprostol for Labor Induction [24N]

Document Type

Article

Publication Date

4-29-2018

Publication Title

Obstetrics and Gynecology

Volume

131

Issue

p

First page number:

158S

Abstract

INTRODUCTION: For labor induction of an unfavorable cervix, we propose oral misoprostol, titrated to uterine response, to maximize safety and efficacy, based upon past studies. METHODS: Randomized double-blinded study. Identically appearing oral and vaginal study dosages were prepared containing either 25mcg misoprostol or placebo. The pharmacist randomized the study participants to receive either an “oral packet” (oral misoprostol, vaginal placebo) or a “vaginal packet” (opposite). Patients received both an oral protocol (quantity of capsules titrated to uterine contractions, every 2hrs) and vaginal protocol (25mcg/placebo every 4hrs) simultaneously. Providers and patients were blinded. (see full text for full abstract)

Disciplines

Obstetrics and Gynecology

Language

English

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