Exposure to Bisphosphonates and Risk of Breast Cancer: A Meta-analysis of Published Observational Studies
Journal of General Internal Medicine
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BACKGROUND: Few studies have observed the association between the use of bisphosphonates and the risk of breast cancer through a possible anti-tumor activity of bisphosphonates. This is a meta-analysis of the available observational studies that aims to further analyze the current available data regarding the association between the use of bisphosphonates and the risk of breast cancer. METHODS: A systematic search of PubMed, MEDLINE/Ovid, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, and Google Scholar through November 10, 2017, identified 5 cohort studies and 3 case-control studies that reported the use of bisphosphonates and risk of breast cancer. Study eligibility and data extraction were performed independently by 3 authors. Random-effects pooled odds ratios and 95% confidence intervals JGIM ABSTRACTS S193 were estimated. Heterogeneity was measured using I2, and a meta-regression analysis was conducted. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to assess the overall quality of the evidence. RESULTS: A total of 955,996 patients from 8 observational studies were analyzed. Bisphosphonates exposure reduced the risk of breast cancer by 28.2% (pooled odds ratio, 0.718; 95% confidence interval, 0.634 to 0.814; p
Medicine and Health Sciences
Exposure to Bisphosphonates and Risk of Breast Cancer: A Meta-analysis of Published Observational Studies.
Journal of General Internal Medicine, 33(supp 2),