Title

Influenza Vaccine Effectiveness Estimates Against Influenza A(H3N2) and A(H1N1) Pdm09 Among Children During School-Based Outbreaks in the 2016–2017 Season in Beijing, China

Document Type

Article

Publication Date

11-1-2019

Publication Title

Human Vaccines & Immunotherapeutics

Volume

18

Issue

10

First page number:

1

Last page number:

8

Abstract

Background: Since 2007, trivalent inactivated influenza vaccine (TIV) has been provided free-of-charge to primary, middle school and high school students in Beijing. However, there have been few school-based studies on influenza vaccine effectiveness (VE). In this report, we estimated influenza VE against laboratory-confirmed influenza illness among school children in Beijing, China during the 2016-2017 influenza season. Methods: The VE of 2016-2017 TIV against laboratory-confirmed influenza virus infection among school-age children was assessed through a case-control design. Conditional logistic regression was conducted on matched case-control sets to estimate VE. The effect of prior vaccination on current VE was also examined. Results: All 176 samples tested positive for influenza A virus with the positive rate of 55.5%. The average coverage rate of 2016-2017 TIV among students across the 37 schools was 30.6%. The fully adjusted VE of 2016-2017 TIV against laboratory-confirmed influenza was 69% (95% CI: 51 to 81): 60% (95% CI: -15 to 86) for influenza A(H1N1)pdm09 and 73% (95% CI: 52 to 84) for influenza A(H3N2). The overall VE for receipt of 2015-2016 vaccination only, 2016-2017 vaccination only, and vaccinations in both seasons was 46% (95% CI: -5 to 72), 77% (95% CI: 58 to 87), and 57% (95%CI: 17 to 78), respectively. Conclusions: Our study during school outbreaks found that VE of 2016-2017 TIV was moderate against influenza A(H3N2) as well as A(H1N1)pdm09 viruses.

Keywords

Influenza; vaccine effectiveness; school; children; outbreak; China

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Medicine and Health Sciences | Therapeutics

Language

English

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