EUS-Guided Biliary Drainage: A Systematic Review and Meta-Analysis

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Endoscopic Ultrasound





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ERCP is the current procedure of choice for patients with jaundice caused by biliary obstruction. EUS‑guided biliary drainage (EUS‑BD) has emerged as an alternative to ERCP in patients requiring biliary drainage. The aim of the study was to conduct a systematic review and meta‑analysis to report the overall efficacy and safety of EUS‑BD. We conducted a comprehensive search of several databases including PubMed, EMBASE, Web of Science, Google Scholar, and LILACS databases (earliest inception to June 2018) to identify studies that reported EUS‑BD in patients. The primary outcome was to look at the technical and clinical success of the procedure. The secondary analysis focused on calculating the pooled rate of re‑interventions and all adverse‑events, along with the commonly reported adverse‑event subtypes. Twenty‑three studies reporting on 1437 patients were identified undergoing 1444 procedures. Majority of the patient population were male (53.86%), with an average age of 67.22 years. The pooled technical success rates and clinical success rates were 91.5% (95% confidence interval [CI]: 87.7–94.2, I2 = 76.5) and 87% (95% CI: 82.3–90.6, I2 = 72.4), respectively. The total adverse event rates were 17.9% (95% CI: 14.3–22.2, I2 = 69.1). Subgroup analysis of three major individual adverse events was bile leak: 4.1% (2.7–6.2, I2 = 46.7), stent migration: 3.9% (2.5–6.2, I2 = 43.5), and infection: 3.8% (2.8–5.1, I2 = 0) Substantial heterogeneity was noted in the analysis. EUS‑BD has high technical and clinical success rate and hence a very effective procedure. Concerns about publication bias exist. Careful consideration should be given to the adverse events and weighing the risks and benefits of the alternative nonsurgical/surgical approaches.


Biliary Drainage; Biliary Obstruction; ERCP; EUS Guided; Jaundice


Gastroenterology | Medical Specialties | Medicine and Health Sciences



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