Title
Relationships Between Frontal Metabolites and Alzheimer’s Disease Biomarkers in Cognitively Normal Older Adults
Document Type
Article
Publication Date
1-1-2022
Publication Title
Neurobiology of Aging
Volume
109
First page number:
22
Last page number:
30
Abstract
Elevated expression of β-amyloid (Aβ1-42) and tau are considered risk-factors for Alzheimer's disease in healthy older adults. We investigated the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on 1) frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and 2) cognition in cognitively normal older adults (n = 144; age range 50-85). Levels of frontal gamma aminobutyric acid (GABA+) and myo-inositol relative to creatine (mI/tCr) were predicted by age. Levels of GABA+ predicted cognitive performance better than mI/tCr. Additionally, we found that frontal levels of n-acetylaspartate relative to creatine (tNAA/tCr) were predicted by levels of t-tau. In cognitively normal older adults, levels of frontal GABA+ and mI/tCr are predicted by aging, with levels of GABA+ decreasing with age and the opposite for mI/tCr. These results suggest that age- and biomarker-related changes in brain metabolites are not only located in the posterior cortex as suggested by previous studies and further demonstrate that MRS is a viable tool in the study of aging and biomarkers associated with pathological aging and Alzheimer's disease.
Keywords
Aging; Alzheimer's disease; Cerebrospinal fluid biomarkers; Frontal cortex; General cognition; Magnetic resonance spectroscopy
Disciplines
Cognitive Neuroscience | Neurosciences
Repository Citation
Hone-Blanchet, A.,
Bohsali, A.,
Krishnamurthy, L.,
Shahid, S.,
Lin, Q.,
Zhao, L.,
Loring, D.,
Goldstein, F.,
John, S. E.,
Fleischer, C.,
Levey, A.,
Lah, J.,
Qiu, D.,
Crosson, B.
(2022).
Relationships Between Frontal Metabolites and Alzheimer’s Disease Biomarkers in Cognitively Normal Older Adults.
Neurobiology of Aging, 109
22-30.
http://dx.doi.org/10.1016/j.neurobiolaging.2021.09.016