Master of Science (MS)
Kinesiology and Nutrition Sciences
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Background: Hunger hormone levels are typically dysregulated in obese and diabetic
populations, however; postprandial exercise has been shown to influence hunger hormone levels. Purpose: To determine if hunger hormones including acylated ghrelin and GLP-1 levels are altered in response to an acute bout (15 minutes) of walking in individuals at risk for type 2 diabetes mellitus (T2DM).
Methods: Ten subjects at risk for prediabetes (fasting blood glucose 100–125mg/dL) participated in this randomized crossover design trial. Subjects arrived at the laboratory following an overnight fast and underwent one of two conditions: 1) Test meal with no walking (CON) or 2) Test meal followed by a 15-minute treadmill walk at preferred walking speed (WALK). Blood samples were taken over two hours and assayed for acylated ghrelin and active GLP-1. A repeated measures ANOVA was used to compare mean differences for all outcome variables.
Results: There were no statistical differences in acylated ghrelin (F = 1.535, p = 0.247) or GLP-1 (F = 0.003, p = 0.955) concentrations between CON and WALK conditions at any time period. There was a main effect of time for ghrelin (F = 41.339; p < 0.001). Post hoc analysis indicated a significant difference between baseline and 60 minutes (p < 0.001) and between baseline and 120 minutes (p < 0.001) for acylated ghrelin concentrations. No difference was found between 60 minutes and 120 minutes (p = 0.834). There was a main effect of time for GLP-1 (F = 17.968; p < 0.001). Post hoc analysis indicated a significant difference between baseline and 60 minutes (p = 0.001) and between baseline and 120 minutes (p = 0.002) for GLP-1 concentrations. No difference was found between 60 minutes and 120 minutes (p = 0.665). There was no significant difference in the AUC for acylated ghrelin between the CON and WALK conditions (t = -1.257;
p = 0.240). There was no significant difference in the AUC for GLP-1 between the CON and WALK conditions (t = -0.107; p = 0.918). Correlations between perceived hunger and biological hunger were weak and nonsignificant (p > 0.05).
Conclusion: A 15-minute walk performed shortly after a meal does not have a significant impact on hunger hormones including acylated ghrelin and active GLP-1 concentrations in individuals at risk for T2DM.
Diabetes; Hunger Hormones; Obesity; Postprandial; Walking
Kinesiology | Medicine and Health Sciences | Nutrition
University of Nevada, Las Vegas
Spoon, Sydney, "The Effects of an Acute Bout of Exercise on Hunger Hormones in Individuals at Risk for Type 2 Diabetes" (2017). UNLV Theses, Dissertations, Professional Papers, and Capstones. 3038.
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