Award Date

August 2024

Degree Type

Dissertation

Degree Name

Doctor of Philosophy (PhD)

Department

Computer Science

First Committee Member

Kazem Taghva

Second Committee Member

Laxmi Gewali

Third Committee Member

Wolfgang Bein

Fourth Committee Member

Mingon Kang

Fifth Committee Member

Emma Regentova

Number of Pages

108

Abstract

In this work, we report on a series of natural language processing tools and models to improve the efficiency and accuracy of information discovery from clinical trials and pharmacological studies. Our main contributions are: 1. The development of an open-source platform Tri-AL that • Enables dynamic tracking of clinical trials information over time, • Excels in data visualization and user interaction with a particular emphasis on enhancing the analysis and representation of race and ethnicity data to foster equity in clinical research, and • Includes a predictive model utilizing machine learning to decipher drug mechanisms of action. 2. Heterogeneous Graph Neural Network for Gene-Chemical Entity Relation Extraction: We created a supervised deep learning model that adapts a heterogeneous Graph Neural Network to extract gene-chemical components. This model augments word representations using message passing that accurately identifies gene-chemical named entities and their relationships class. 3. Bipartite Graph Model for Evaluating Summarization Performance: We proposed a bipartite graph model to evaluate the performance of large language models in summarizing clinical trials. This model provides a robust framework to assess the accuracy and effectiveness of automated summarization tools in the medical domain.

Disciplines

Engineering

Degree Grantor

University of Nevada, Las Vegas

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

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