A MEMS-based Electronic Capsule for Time Controlled Drug Delivery in the Alimentary Canal

Authors

Yinping Zhuang, Chongqing University
Wensheng Hou, Chongqing UniversityFollow
Xiaolin Zheng, Chongqing UniversityFollow
Zhigang Wang, University of Dundee
Jun Zheng, New Mexico Institute of Mining and TechnologyFollow
Xtian Pi, Chongqing UniversityFollow
Jianguo Cui, Chongqing University
Yingtao Jiang, University of Nevada, Las VegasFollow
Shizhi Qian, Old Dominion UniversityFollow
Chenglin Peng, Chongqing UniversityFollow

Document Type

Article

Publication Date

9-10-2011

Publication Title

Sensors and Actuators, A: Physical

Volume

169

First page number:

211

Last page number:

216

Abstract

A controlled drug delivery system (CDDS) that is capable of releasing right dose of drug in the alimentary canal at the prespecified time has been designed, fabricated and tested. This micro-electro-mechanical system (MEMS)-based CDDS, in the form of an electronic capsule, has four major components: a timer module for controlling drug release, a driving unit for releasing drug to the alimentary canal, a microfluidic chamber for drug reservoir, and a power supply. Of these four components, the timer module is the most critical one as it needs to provide precise timing points for drug release and must have a simple mechanism for setting up timing parameters externally. To this end, a microcontroller has been employed to realize the timer, while an external resistance network is used to program the timing parameter. The performance of the electronic capsule is evaluated through in vitro and in vivo animal experiments. The preliminary results have confirmed that the electronic capsule can release drug reliably and effectively at the scheduled time points.

Keywords

Alimentary canal; Controlled drug delivery system; Micro-electro-mechanical system (MEMS); Timing electronic capsule

Disciplines

Controls and Control Theory | Electrical and Computer Engineering | Electrical and Electronics | Electromagnetics and Photonics | Electronic Devices and Semiconductor Manufacturing | Signal Processing | Systems and Communications

Language

English

Permissions

Use Find in Your Library, contact the author, or interlibrary loan to garner a copy of the item. Publisher policy does not allow archiving the final published version. If a post-print (author's peer-reviewed manuscript) is allowed and available, or publisher policy changes, the item will be deposited.

Repository Citation

Zhuang, Y., Hou, W., Zheng, X., Wang, Z., Zheng, J., Pi, X., Cui, J., Jiang, Y., Qian, S., Peng, C. (2011). A MEMS-based Electronic Capsule for Time Controlled Drug Delivery in the Alimentary Canal. Sensors and Actuators, A: Physical, 169 211-216.