A Model for the Modulation of Microvessel Permeability by Junction Strands

Document Type

Article

Publication Date

10-2003

Publication Title

Journal of Biomechanical Engineering

Volume

125

Issue

5

First page number:

620

Last page number:

627

Abstract

To investigate the effect of junction strands on microvessel permeability, we extend the previous analytical model developed by Fu et al. (1994, J. Biomech. Eng., 116, pp. 502-513), for the interendothelial cleft to include multiple junction strands in the cleft and an interface between the surface glycocalyx layer and the cleft entrance. Based on the electron microscopic observations by Adamson et al. (1998, Am. J. Physiol., 274(43), pp. H1885-H1894), that elevation of intracellular cAMP levels would increase number of tight junction strands, this two-junction-strand and two-pore model can successfully account for the experimental data for the decreased permeability to water, small and intermediate-sized solutes by cAMP.

Keywords

Cells – Permeability; Endothelial cells; Glycoproteins; Tissues – Permeability; Water

Disciplines

Biomechanics and Biotransport | Biomedical Engineering and Bioengineering | Molecular, Cellular, and Tissue Engineering

Language

English

Permissions

Use Find in Your Library, contact the author, or interlibrary loan to garner a copy of the item. Publisher policy does not allow archiving the final published version. If a post-print (author's peer-reviewed manuscript) is allowed and available, or publisher policy changes, the item will be deposited.


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