Indices of leukocyte infiltration and muscle recovery after eccentric contraction-induced injury in young and adult male mice

Document Type

Article

Publication Date

11-2005

Publication Title

Orthopaedic Nursing

Volume

24

Issue

6

First page number:

399

Last page number:

405

Abstract

The movement of leukocytes (e.g., neutrophils and macrophages) into skeletal muscle is a critical response after a sports-related injury. Age could influence this response. The major objectives of the study were to determine whether there is a relationship between age and the degree of (1) leukocyte response and (2) muscle recovery. The left plantarflexor muscles of 42 young and adult male mice underwent eccentric contractions, which can cause injury. After 1 or 5 days, leukocyte infiltration and muscle recovery were assessed in the soleus or medial gastrocnemius muscles. No relationship between age and leukocyte infiltration was found (P = .36). Neutrophils, but not macrophages, were detected at 1-day recovery. A significant relationship between age and muscle recovery was detected (P = .0498), suggesting that muscle recovery may be decreased with increased age.

Keywords

Aging/pathology; Animals; Healing; Leucocytes; Leukocytes/pathology; Male; Mice; Mice – Wounds and injuries; Mice; Inbred C57BL; Muscle contraction; Muscle; Skeletal/injuries; Muscle; Skeletal/pathology; Muscle; Skeletal/physiopathology; Muscles – Wounds and injuries; Older people – Wounds and injuries; Sports injuries

Disciplines

Medicine and Health Sciences | Nursing | Orthopedics

Language

English

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