Title

Cytokines in exertion-induced skeletal muscle injury

Document Type

Article

Publication Date

2-1998

Publication Title

Molecular and Cellular Biochemistry

Volume

179

Issue

1-2

First page number:

159

Last page number:

168

Abstract

Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. The biological actions and potential adaptive values of these cytokines through the course of muscle necrosis and regeneration will be described.

Keywords

Cytokines; Exercise; Fibroblasts; Leucocytes; Leukocyte; Muscles – Regeneration; Muscles – Wounds and injuries; Necrosis; Neutrophils; Regeneration; Regeneration (Biology); Skeletal muscle; Tumor necrosis factor

Disciplines

Kinesiology | Medicine and Health Sciences | Nursing

Language

English

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