Title

Shank3 as a potential biomarker of antidepressant response to ketamine and its neural correlates in bipolar depression

Document Type

Article

Abstract

Shank3, a post-synaptic density protein involved in N-methyl-d-aspartate (NMDA) receptor tethering and dendritic spine rearrangement, is implicated in the pathophysiology of bipolar disorder. We hypothesized that elevated baseline plasma Shank3 levels might predict antidepressant response to the NMDA receptor antagonist ketamine.

Disciplines

Nursing