Document Type
Article
Publication Date
5-25-2011
Publication Title
PLoS One
Volume
6
Issue
5
First page number:
1
Last page number:
17
Abstract
Many bioinformatic databases and applications focus on a limited domain of knowledge federating links to information in other databases. This segregated data structure likely limits our ability to investigate and understand complex biological systems. To facilitate research, therefore, we have built HIVToolbox, which integrates much of the knowledge about HIV proteins and allows virologists and structural biologists to access sequence, structure, and functional relationships in an intuitive web application. HIV-1 integrase protein was used as a case study to show the utility of this application. We show how data integration facilitates identification of new questions and hypotheses much more rapid and convenient than current approaches using isolated repositories. Several new hypotheses for integrase were created as an example, and we experimentally confirmed a predicted CK2 phosphorylation site.
Keywords
Bioinformatics; Biologists; Database management--Computer programs; Databases; HIVToolbox; HIV (Viruses); Virologists; Web applications
Disciplines
Bioinformatics | Biology | Immune System Diseases | Life Sciences | Structural Biology | Virus Diseases
Language
English
Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.
Repository Citation
Sargeant, D. P.,
Deverasetty, S.,
Luo, Y.,
Baleta, A. V.,
Zobrist, S.,
Rathnayake, V.,
Russo, J. C.,
Vyas, J.,
Muesing, M. A.,
Schiller, M.
(2011).
HIVToolbox, an Integrated Web Application for Investigating HIV.
PLoS One, 6(5),
1-17.
http://dx.doi.org/10.1371/journal.pone.0020122
Included in
Bioinformatics Commons, Biology Commons, Immune System Diseases Commons, Structural Biology Commons, Virus Diseases Commons