Minimotif Miner, a tool for investigating protein function

Authors

Sudha Balla, Memorial Sloan-Kettering Cancer CenterFollow
Vishal Thapar, University of Connecticut - StorrsFollow
Snigdha Verma, University of Connecticut - Storrs
ThaiBinh Luong, University of Connecticut - Storrs
Tanaz Faghri, University of Connecticut - Storrs
Chun-Hsi Huang, University of Connecticut - StorrsFollow
Sanguthevar Rajasekaran, University of Connecticut - StorrsFollow
Jacob J. del Campo, University of Connecticut - Storrs
Jessica H. Shinn, University of Connecticut - Storrs
William A. Mohler, University of Connecticut - Storrs
Mark W. Maciejewski, University of Connecticut Health CenterFollow
Michael R. Gryk, University of Connecticut Health CenterFollow
Bryan Piccirillo, University of Connecticut Health Center
Stanley R. Schiller
Martin R. Schiller, University of Nevada, Las VegasFollow

Document Type

Article

Publication Date

3-2006

Publication Title

Nature Methods

Volume

3

Issue

3

First page number:

175

Last page number:

177

Abstract

In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.

Keywords

14-3-3 Proteins/chemistry; 14-3-3 Proteins/physiology; Amino Acid Motifs; Amino acid sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins/chemistry; Caenorhabditis elegans Proteins/physiology; Databases; Databases as Topic; Internet; Membrane Glycoproteins/chemistry; Membrane Glycoproteins/physiology; Minitof Miner; Molecular Sequence Data; Proteins/chemistry; Proteins/physiology; Sequence Alignment; Sequence alignment (Bioinformatics); Sequence Analysis; Protein/methods; Software

Disciplines

Computer Sciences | Genetics and Genomics | Life Sciences | Molecular Biology | Neurosciences | Structural Biology

Language

English

Repository Citation

Balla, S., Thapar, V., Verma, S., Luong, T., Faghri, T., Huang, C., Rajasekaran, S., del Campo, J. J., Shinn, J. H., Mohler, W. A., Maciejewski, M. W., Gryk, M. R., Piccirillo, B., Schiller, S. R., Schiller, M. R. (2006). Minimotif Miner, a tool for investigating protein function. Nature Methods, 3(3), 175-177.
http://dx.doi.org/10.1038/NMETH856