Receptors | Platelet-Activating Factor Receptor
Encyclopedia of Biological Chemistry: Third Edition
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The platelet-activating factor receptor (PAFR) is a G-protein-coupled seven-transmembrane spanning receptor involved in both normal physiological and numerous pathophysiological processes. Stimulation of the receptor via binding of the lipid molecule, PAF, elicits diverse and potent biological activities and plays a profound role in acute inflammation, allergic disorders, endotoxic shock, and anaphylaxis. The PAFR gene, located on chromosome 1, produces two PAFR transcripts with unique cellular and tissue distributions. Regulation of PAFR signaling results from varying the rates of synthesis and degradation of PAF, altering receptor expression levels, receptor internalization, and desensitization of the receptor.
Amino Acids, Peptides, and Proteins | Biological Factors
Howard, K. M.,
Receptors | Platelet-Activating Factor Receptor.
Encyclopedia of Biological Chemistry: Third Edition, 6