Title
Physics of photodynamic therapy
Document Type
Book Section
Publication Date
1-1-2016
Publication Title
Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery
Publisher
Springer New York
First page number:
287
Last page number:
309
Abstract
Photodynamic therapy (PDT) uses light-activated drugs (photosensitizers) for the treatment of neoplastic and non-neoplastic diseases. Administration of the photosensitizer constitutes the first step in the PDT process. Then, following a waiting period (minutes to days) to allow for selective accumulation in the target tissue, the sensitizer is activated via light (usually from a laser) of a wavelength matching a prominent absorption resonance in the red or near-infrared part of the visible spectrum. Absorption of this light by the photosensitizer results in photochemical processes which ultimately produce the cytotoxic species (e.g., singlet molecular oxygen) responsible for the biological damage. © Springer Science+Business Media New York 2016. All rights reserved.
Keywords
Diffusion approximation; Monte Carlo simulation; PDT dosimetry; Photodynamic therapy; Radiation transport
Language
English
Repository Citation
Madsen, S.
(2016).
Physics of photodynamic therapy.
Biomedical Optics in Otorhinolaryngology: Head and Neck Surgery
287-309.
Springer New York.
http://dx.doi.org/10.1007/978-1-4939-1758-7_18