Alzheimer’s Disease; ROS; CRANAD-X; Amyloidβ aggregates
Medicine and Health Sciences
Alzheimer's Disease (AD), is a progressive neurodegenerative disease that is fatal. Amyloid β (Aβ) aggregates are produced in the relation between AD and its later stages. While AD is not necessarily present because of the Aβ aggregates, they are however a cohesive sublimate of each other within the later stages of the disease. Currently there are no drug preventative measures that have been successful in bringing treatment to the Aβ aggregates. It has been shown that AD had been most closely associated with the production of Aβ aggregates in relation to the progression of the disease. However, in regards to the lack of preventative measures in Aβ aggregates it is suggested that reactive oxygen species (ROS) should be taken into consideration when taking drug related measures. Specifically speaking it has been found that ROS levels are significantly higher in brains with AD than in brains that are healthy. Taking into consideration both the ROS levels, as well as the Aβ aggregates, it can be beneficial in detecting AD early on in order to take preventative measures.
CRANAD-X is a family of curcumin analogue molecules which have previously been used in NIRF (Near Infra-Red Fluorescence spectroscopy) imaging. This study is to show the computa-tional values of each prospective system for an experimental value such as excitation, emission, and wavelength emission. Experimental values found in this computational study will help to further a close approximation to other molecules that are similar in structure in other experimental investigations. Similar molecules found in this study could be used for probes to detect Aβ aggregates, and ROS levels.
Phillips, Elizabeth and Shao, PhD, Yin
"Computational Oxalate-Curcumin Based Probe Molecules for Functionality in Alzheimer's Disease,"
Journal of Health Disparities Research and Practice: Vol. 12
, Article 39.
Available at: https://digitalscholarship.unlv.edu/jhdrp/vol12/iss4/39