Title

A Charge-Filtration-Diffusion Model for Microvessel Permeability

Document Type

Conference Proceeding

Publication Date

2002

Publication Title

Proceedings of the 2002 IEEE Engineering in Medicine and Biology

Publisher

IEEE

Volume

1

First page number:

839

Last page number:

840

Abstract

Endothelial surface glycocalyx plays an important role in the regulation of microvessel permeability by possibly changing its charge and configuration. To investigate the mechanisms of how surface properties of the endothelial cells control the changes in microvessel permeability, we extended the charge-diffusion model developed by Fu et al. (2002) for the interendothelial cleft with a negatively charged surface glycocalyx layer, to include the filtration due to hydrostatic and oncotic pressures across the microvessel wall, as well as the electrical potential across the surface fiber layer. Based on hypotheses proposed in Curry (1994), the predictions from this charge-filtration-diffusion model provided a remarkably good agreement with experimental data for permeability of negatively charged α-lactalbumin summarized in Curry (1994) under various conditions.

Keywords

Biodiffusion; Bioelectric phenomena; Blood-vessels; Cell membranes – Electric properties; Cells – Permeability; Electrophysiology; Endothelial cells; Filtration; Glycoproteins; Haemorheology; Permeability; Physiological models

Disciplines

Biomedical Engineering and Bioengineering | Engineering | Mechanical Engineering | Molecular, Cellular, and Tissue Engineering

Language

English

Permissions

Use Find in Your Library, contact the author, or interlibrary loan to garner a copy of the item. Publisher policy does not allow archiving the final published version. If a post-print (author's peer-reviewed manuscript) is allowed and available, or publisher policy changes, the item will be deposited.

Identifier

DOI: http://dx.doi.org/10.1109/IEMBS.2002.1137102

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