X-Ray Fluorescence Computed Tomography for Molecular Imaging
Editors
C.H. Chen (Ed.)
Document Type
Book Section
Publication Date
1-1-2015
Publication Title
Frontiers of Medical Imaging
Publisher
World Scientific
Publisher Location
Singapore
First page number:
83
Last page number:
98
Abstract
X-ray fluorescence computed tomography (XFCT) is a promising technique able to identify and quantify features in small samples of high-atomic-number (Z) elements such as iodine, gadolinium and gold. In this chapter, as a proof-of-concept, we investigated the feasibility of simultaneously imaging multiple elements (multiplexing) using XFCT. A polychromatic X-ray source was used to stimulate emission of X-ray fluorescence photons from multiple high-Z elements with low concentrations [2% (weight/volume) gold (Au), gadolinium (Gd) and barium (Ba)] embedded within a water phantom. The water phantom was used to mimic biological tissue targeted with high-Z nanoprobes. The emitted X-ray energy spectra from three elements were collected and then used to isolate the K shell X-ray fluorescence peaks and to generate sinograms for the three elements of interest. The tomographic distribution of the high Z elements within the phantom was reconstructed. A linear relationship between the X-ray fluorescence intensity of tested elements and their concentrations was observed, suggesting that XFCT is capable of quantitative molecular imaging.
Language
eng
Repository Citation
Li, X.,
Kuang, Y.
(2015).
X-Ray Fluorescence Computed Tomography for Molecular Imaging. In C.H. Chen (Ed.),
Frontiers of Medical Imaging
83-98.
Singapore: World Scientific.
http://dx.doi.org/10.1142/9789814611107_0005