Algorithms for Local Structural Alignment And Structural Motif Identification

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A protein is characterized by both the amino-acid sequence and the threedimensional (3-D) structure of the underlying atoms. Although it is a common practice of the biologists to use sequence similarity among different proteins to identify any conserved regions during the evolution, it has been proven that the 3-D structures of the proteins are conserved more fundamentally than the sequence during the evolution. Even though two given proteins may not exhibit much of a sequence homology, the structural similarity between them might account for similar properties. Proteins with a similar structure might have similar properties. This is the motivation behind the study of the structural alignment problem in a manner similar to that of the sequence alignment problem.


Biochemistry, Biophysics, and Structural Biology | Computational Biology | Molecular Biology