Proline Sulfonamide-Catalyzed, Domino Process for Asymmetric Synthesis of Amino- and Hydroxy-Substituted Bicyclo[2.2.2]octanes
Document Type
Article
Publication Date
11-25-2015
Publication Title
European Journal of Organic Chemistry
Volume
2016
Issue
1
First page number:
150
Last page number:
157
Abstract
A generalized method for accessing highly functionalized amino-substituted bicyclo[2.2.2]octanes via p-dodecylphenylsulfonamide catalyst in a good enantio- and diastereoselective fashion has been developed. A discussion of the mechanistic underpinnings of this transformation is presented. Finally, an unexpected discovery enabling the extension of this protocol to the synthesis of OH-substituted bicyclo[2.2.2]octanes with encouraging levels of stereoselectivity is discussed.
Repository Citation
Mohamed, E.,
Kang, J. Y.,
Lingampally, R.,
Carter, R. G.
(2015).
Proline Sulfonamide-Catalyzed, Domino Process for Asymmetric Synthesis of Amino- and Hydroxy-Substituted Bicyclo[2.2.2]octanes.
European Journal of Organic Chemistry, 2016(1),
150-157.
http://dx.doi.org/10.1002/ejoc.201501302