Cefoxitin vs. Penicillin in the Treatment of Uncomplicated Gonorrhea

Document Type

Article

Publication Date

1983

Publication Title

Sexually Transmitted Diseases

Volume

10

Issue

2

First page number:

53

Last page number:

55

Abstract

Four hundred six men and women with gonorrhea were randomly assigned to receive either 2 g of cefoxitin or 4.8 X 10(6) units of aqueous procaine penicillin G intramuscularly. All patients also received 1 g of probenecid orally. There was no statistically significant difference in the failure rate between patients treated with penicillin (4.3%) and those treated with cefoxitin (5.1%). Twelve (92%) of 13 homosexual men with gonococcal proctitis who received penicillin and 19 (95%) of 20 who received cefoxitin were cured. Adverse reactions were infrequent and mild in the cefoxitin-treated group. Three patients who received penicillin developed reactions consistent with procaine toxicity. It is concluded that cefoxitin is a safe and effective alternative to penicillin for treating uncomplicated anogenital gonorrhea in men and women.

Keywords

Antibiotics; Clinical trials; Drugs – Testing; Gonorrhea

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Community Health | Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Pharmacy and Pharmaceutical Sciences

Language

English

Permissions

Use Find in Your Library, contact the author, or use interlibrary loan to garner a copy of the article. Publisher copyright policy allows author to archive post-print (author’s final manuscript). When post-print is available or publisher policy changes, the article will be deposited

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