Cefoxitin vs. Penicillin in the Treatment of Uncomplicated Gonorrhea
Document Type
Article
Publication Date
1983
Publication Title
Sexually Transmitted Diseases
Volume
10
Issue
2
First page number:
53
Last page number:
55
Abstract
Four hundred six men and women with gonorrhea were randomly assigned to receive either 2 g of cefoxitin or 4.8 X 10(6) units of aqueous procaine penicillin G intramuscularly. All patients also received 1 g of probenecid orally. There was no statistically significant difference in the failure rate between patients treated with penicillin (4.3%) and those treated with cefoxitin (5.1%). Twelve (92%) of 13 homosexual men with gonococcal proctitis who received penicillin and 19 (95%) of 20 who received cefoxitin were cured. Adverse reactions were infrequent and mild in the cefoxitin-treated group. Three patients who received penicillin developed reactions consistent with procaine toxicity. It is concluded that cefoxitin is a safe and effective alternative to penicillin for treating uncomplicated anogenital gonorrhea in men and women.
Keywords
Antibiotics; Clinical trials; Drugs – Testing; Gonorrhea
Disciplines
Analytical, Diagnostic and Therapeutic Techniques and Equipment | Community Health | Female Urogenital Diseases and Pregnancy Complications | Male Urogenital Diseases | Pharmacy and Pharmaceutical Sciences
Language
English
Permissions
Use Find in Your Library, contact the author, or use interlibrary loan to garner a copy of the article. Publisher copyright policy allows author to archive post-print (author’s final manuscript). When post-print is available or publisher policy changes, the article will be deposited
Repository Citation
Greaves, W. L.,
Kraus, S. J.,
McCormack, W. M.,
Biddle, J. W.,
Zaidi, A.,
Fiumara, N. J.,
Guinan, M.
(1983).
Cefoxitin vs. Penicillin in the Treatment of Uncomplicated Gonorrhea.
Sexually Transmitted Diseases, 10(2),
53-55.
