Document Type

Article

Publication Date

3-5-2020

Publication Title

Molecules

Publisher

MDPI

Volume

25

Issue

5

First page number:

1

Last page number:

36

Abstract

Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.

Keywords

Chemotherapy-induced peripheral neuropathy; Chronic constriction injury; Diabetic neuropathy; Diabetic painful neuropathy; Flavonoids; Oxidative stress; Partial sciatic nerve injury; Peripheral neuropathy; Spared nerve injury; Spinal nerve ligation

Disciplines

Nervous System Diseases | Pain Management

File Format

pdf

File Size

22.492 KB

Language

English

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