Award Date

8-1-2014

Degree Type

Thesis

Degree Name

Master of Science (MS)

Department

Kinesiology and Nutrition Sciences

First Committee Member

Laura Kruskall

Second Committee Member

James Navalta

Third Committee Member

Richard Tandy

Fourth Committee Member

John Young

Fifth Committee Member

Sue Schuerman

Number of Pages

76

Abstract

Purpose: Waist circumference has been shown to have a link to various forms of chronic disease and low levels of Vitamin D (25(OH)D) and IGF-1. The purpose of this study is to assess if there is a relationship with Vitamin D (25(OH)D) and IGF-1 levels and waist circumference.

Methods: As part of a cross-sectional correlation study, participants were males and females (n=26), ages 25-65, who were students at UNLV and/or individuals who attend local health and wellness facilities as well as attendees of classes held by the UNLV Nutrition Center. Participants reported to UNLV to review and sign informed consent and submit a finger stick blood draw under sterile conditions as well as resting blood pressure and waist circumference. The finger stick blood draw sample was used to obtain serum 25(OH)D and IGF-1 levels using ELISA kits. Participants completed food frequency questionnaires asking about eating habits prior to study and surveys were administered to determine level and type of physical activity. Participants then reported to a local Quest Diagnostics at their convenience to obtain a fasting comprehensive metabolic panel. Data were collected and evaluated using Microsoft Excel and SPSS software.

Results: Subjects were separated into two groups according to waist circumference (Female >35", Male >40") Data reflected no significant difference between large waist and normal waist circumference groups in regards to both IGF-1 and 25(OH)D. Data did reflect, however, that a significant relationship between IGF-1 and waist circumference did exist (P=.006). Although, a significant relationship between 25(OH)D and waist circumference did not exist.

Conclusion: Waist circumference has an inverse relationship to IGF-1. Abdominal obesity may cause a reduction in the amount of free IGF-1 produced by the body which could increase risk for chronic disease. Obtaining waist circumference as well as activity level is relatively convenient in medical treatment settings and could provide clinicians with more valuable information regarding patient's level of risk for disease.

Keywords

Abdomen – Measurement; Body size; Diseases – Risk factors; Obesity; Somatomedin; Vitamin D; Vitamin D in the body

Disciplines

Human and Clinical Nutrition | Kinesiology | Molecular, Genetic, and Biochemical Nutrition | Nutrition

Language

English


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