Regulation of Cancer Stem Cells by Protein Post-Translational Modifications

Authors

Emily Khanh Pham, University of Nevada, Las VegasFollow
Hui Zhang, University of Nevada, Las VegasFollow

Funder

Center for Academic Enrichment and Outreach

Document Type

Poster

Publication Date

2016

Publisher

University of Nevada, Las Vegas; Center for Academic Enrichment and Outreach

Publisher Location

Las Vegas (Nev.)

Abstract

Various diseases are caused by defective genes or mutations within the DNA. These mutations can cause cancer cells, which are usually treated through chemotherapy and radiation. However, these methods have not completely effective towards cancer stem cells, a group of cancer cells that possess stem cell properties and are capable of initiating cancer. In order to discover new methods of targeting these specific cells, technology for genome engineering will enable researchers to further study genetic requirements within these cells. The method of clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 will help cleave and alter genomic sequences to potentially correct the genomic mutations caused by the cancer stem cell. Using the technology of CRISPR-Cas9, studies of these cells and growth requirements can help discover new ways to target the cancer stem cell as a new method of therapy.

Keywords

Cancer Cells; mutations; CRISPR-Cas9

Disciplines

Cells | Medicine and Health Sciences

File Format

pdf

File Size

792 KB

Language

English

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/

Repository Citation

Pham, E. K., Zhang, H. (2016). Regulation of Cancer Stem Cells by Protein Post-Translational Modifications.
Available at: https://digitalscholarship.unlv.edu/aanapisi_posters/9