Document Type
Article
Publication Date
4-14-2020
Publication Title
BioMed Research International
Volume
2020
First page number:
1
Last page number:
14
Abstract
The purpose of this study was to investigate the effect of photothermal treatment (PTT) with gold nanoshell (ANS) using a macrophage-mediated delivery system in a head and neck squamous cell carcinoma (HNSCC) cell line. To achieve this, ANS-loaded rat macrophages (ANS-MAs) were prepared via the coculture method with ANS. The human HNSCC (FaDu cell) and macrophage (rat macrophage; NR8383 cell) hybrid spheroid models were generated by the centrifugation method to determine the possibility of using ANS-MAs as a cancer therapy. These ANS-MAs were set into the tumor and macrophage hybrid spheroid model to measure PTT efficacy. Kinetic analysis of the spheroid growth pattern revealed that this PTT process caused a decreasing pattern in the volume of the hybrid model containing ANS-MAs... (see article for full abstract).
Disciplines
Biomedical Engineering and Bioengineering
File Format
File Size
3.418 KB
Language
English
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Kang, S. H.,
Lee, Y. K.,
Park, I. S.,
Park, I.,
Hong, S. M.,
Kwon, S. Y.,
Choi, Y. H.,
Madsen, S. J.,
Hirschberg, H.,
Hong, S. J.
(2020).
Biomimetic Gold Nanoshell-Loaded Macrophage for Photothermal Biomedicine.
BioMed Research International, 2020
1-14.
http://dx.doi.org/10.1155/2020/5869235