Title

New Strategies for Activation of Phosphonates/Phosphates to Forge Functional Phosphorus Compounds

Document Type

Article

Publication Date

1-8-2019

Publication Title

Synlett

Volume

30

Issue

6

First page number:

635

Last page number:

641

Abstract

Organophosphonate analogues are important structural motifs that are present in bioactive natural products, pharmaceuticals, and agrochemicals. Because they are useful in a broad range of applications, much effort has focused on developing efficient synthetic methods that enable access to organophosphonates and their derivatives. However, currently available synthetic procedures rely on harsh reaction conditions and are limited to a narrow substrate scope. Our lab has recently made important advances in leveraging inert phosphonates/phosphates into functional phosphorus compounds such as mixed phosphonates, phosphates, and mixed aryl phosphate derivatives. Presented herein is an overview of recent achievements in the synthesis of phosphonate/phosphate derivatives and a summary of our recent accomplishments in Tf2O-promoted activating strategy of phosphonate analogues.

Keywords

Phosphorylation; Phosphonate; Phosphate; Phosphinate; Mixed phosphonate; Mixed phosphate; Triflic anhydride

Disciplines

Chemistry

Language

English

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