Topically Administered Acyclovir in the Treatment of Recurrent Herpes Simplex Genitalis: a Controlled Trial

Document Type

Article

Publication Date

2-1983

Publication Title

Journal of Infectious Diseases

Volume

147

Issue

2

First page number:

336

Last page number:

340

Abstract

Eighty-eight patients with culture-proven recurrent herpes simplex genitalis were entered into a collaborative, randomized, placebo-controlled, double-blind trial to evaluate the efficacy and toxicity of a topical formulation of acyclovir. Patients entered the study within 48 hr of the onset of lesions, and the study medication was applied six times daily for five days. The duration of virus shedding from lesions present at the time of entry into the study was significantly reduced for men who received acyclovir compared with men who received placebo (P less than 0.05). There were no significant differences between the acyclovir- and placebo-treated groups of either sex in time to crusting of lesions, time required for lesions to heal, time to cessation of pain, or in frequency with which new lesions developed during the course of therapy. Mild, transient burning or pain associated with application of the study medication was a common complaint.

Keywords

Antiviral agents; Herpes genitalis – Treatment; Herpes simplex virus

Disciplines

Analytical, Diagnostic and Therapeutic Techniques and Equipment | Diseases | Male Urogenital Diseases | Public Health

Language

English

Permissions

Use Find in Your Library, contact the author, or use interlibrary loan to garner a copy of the article. Publisher copyright policy allows author to archive post-print (author’s final manuscript). When post-print is available or publisher policy changes, the article will be deposited


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