Document Type
Article
Publication Date
1-1-2018
Publication Title
Alzheimer's and Dementia: Translational Research & Clinical Interventions
Publisher
Elsevier
Volume
4
First page number:
357
Last page number:
365
Abstract
Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible, including biomarkers, genomic profiles, cognitive and behavioral phenotypes, high-frequency assessments, and medical imaging. Although these data are incredibly complex, they can potentially be used to understand multi-determinant causal relationships, elucidate modifiable factors, and ultimately customize treatments based on individual parameters. Especially for neurodegenerative diseases, where an effective therapeutic agent has yet to be discovered, there remains a critical need for an interdisciplinary perspective on data and information management due to the number of unanswered questions. Biomedical informatics is a multidisciplinary field that falls at the intersection of information technology, computer and data science, engineering, and healthcare that will be instrumental for uncovering novel insights into neurodegenerative disease research, including both causal relationships and therapeutic targets and maximizing the utility of both clinical and research data. The present study aims to provide a brief overview of biomedical informatics and how clinical data applications such as clinical decision support tools can be developed to derive new knowledge from the wealth of available data to advance clinical care and scientific research of neurodegenerative diseases in the era of precision medicine.
Keywords
Alzheimer's disease; Biomarker; Clinical decision support; Evidence-based practice; Informatics; Learning healthcare; Machine learning; Neurodegenerative disease; Precision medicine
Disciplines
Biomedical Engineering and Bioengineering | Health Services Research
File Format
File Size
741 Kb
Language
English
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Repository Citation
Miller, J. B.,
Shan, G.,
Lombardo, J.,
Jimenez-Maggoria, G.
(2018).
Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases.
Alzheimer's and Dementia: Translational Research & Clinical Interventions, 4
357-365.
Elsevier.
http://dx.doi.org/10.1016/j.trci.2018.03.007
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