Title

Associations between Comorbid TDP-43, Lewy Body Pathology and Neuropsychiatric Symptoms in Alzheimer's Disease

Document Type

Abstract

Publication Date

6-18-2019

Publication Title

Journal of Alzheimer's Disease

Volume

69

Issue

4

First page number:

953

Last page number:

961

Abstract

More than half of the patients with Alzheimer’s disease (AD) have comorbidities including TDP-43 and Lewy bodies, which are also associated with frontotemporal lobar degeneration and dementia with Lewy bodies, respectively. These comorbidities may help explain the overlapping neuropsychiatric symptoms between AD and other dementias. Data on 221 AD patients with Neuropsychiatric Inventory-Questionnaire were obtained from the National Alzheimer’s Coordinating Center. TDP-43 was associated with aberrant motor activity, whereas Lewy bodies were associated with anxiety, irritability, sleep behavior, and appetite problems. The associations between these comorbidities and neuropsychiatric symptoms were more significant for patients with sparse diffuse plaques.

Keywords

Alzheimer's Disease, Lewy body; Neuropsychiatric symptoms: TDP-43

Disciplines

Cognitive Neuroscience | Mental Disorders | Nutritional Epidemiology

Language

English

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