Dental Pulp Stem Cell: A Review of Factors that Influence the Therapeutic Potential of Stem Cell Isolates

Document Type

Article

Publication Date

1-1-2015

Publication Title

Biomaterials and Biomedical Engineering

Volume

2

Issue

2

First page number:

61

Last page number:

69

Abstract

Undifferentiated stem cells are being studied to obtain information on the therapeutic potential of isolates that are produced. Dental Pulp Stem Ccell (DPSC) may provide an abundant supply of highly proliferative, multipotent Mesenchymal Stem Cells (MSC), which are now known to be capable of regenerating a variety of human tissues including bone and other dental structures. Many factors influence DPSC quality and quantity, including the specific methods used to isolate, collect, concentrate, and store these isolates once they are removed. Ancillary factors, such as the choice of media, the selection of early versus late passage cells, and cryopreservation techniques may also influence the differentiation potential and proliferative capacity of DPSC isolates. This literature review concludes that due to the delicate nature of DPSC, more research is needed for dental researchers and clinicians to more fully explore the feasibility and potential for isolating and culturing DPSCs extracted from adult human teeth in order to provide more accurate and informed advice for this newly developing field of regenerative medicine.

Keywords

Dental Pulp Stem Cell (DPSC); isolation; culture; cryopreservation; media; differentiation; biomarkers

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