Biological Response to Peri-Implantitis Treatment

Document Type

Article

Publication Date

7-18-2019

Publication Title

Journal of Periodontal Research

First page number:

1

Last page number:

9

Abstract

Objective To investigate biological markers of peri‐implantitis (PIP) in crevicular fluid before and after surgical and antimicrobial therapy. Material and Methods Forty‐eight participants (24 healthy implants and 24 PIP) were clinically evaluated, and peri‐implant crevicular fluid (PICF) samples were collected at baseline for both groups, and at 3‐months after surgical and antimicrobial treatment (ie, n = 21 PIP completers). Samples were analyzed for interleukin‐1β (IL‐1β), matrix metalloproteinase‐8 (MMP‐8), and macrophage inflammatory protein‐1α (MIP‐1α) using immunoassay and the results compared between groups. Results Peri‐implantitis sites at baseline demonstrated significantly higher mean periodontal probing depths, percentage bleeding on probing (P ≤ 0.001), and mean IL‐1β concentration in PICF compared to healthy implant sites (17.9 vs 1.7 pg/μL; P = 0.02). … See Full text for complete abstract.

Keywords

Biomarkers; Crevicular fluid; Dental implants; Peri‐implantitis

Disciplines

Periodontics and Periodontology

Language

English

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