Title
A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis
Document Type
Book Section
Publication Date
11-16-2019
Publication Title
Advances in Experimental Medicine and Biology
Publisher
Springer Nature
Publisher Location
Cham, Switzerland
Volume
1197
First page number:
79
Last page number:
95
Abstract
Porphyromonas gingivalis is an oral pathogen with the ability to induce oral dysbiosis and periodontal disease. Nevertheless, the mechanisms by which P. gingivalis could abrogate the host–microbe symbiotic relationship leading to oral dysbiosis remain unclear. We have recently demonstrated that P. gingivalis specifically increased the antimicrobial properties of oral epithelial cells, through a strong induction of the expression of PLA2-IIA in a mechanism that involves activation of the Notch-1 receptor. Moreover, gingival expression of PLA2-IIA was significantly increased during initiation and progression of periodontal disease in non-human primates and interestingly, those PLA2-IIA expression changes were concurrent with oral dysbiosis. In this chapter, we present an innovative hypothesis of a potential mechanism involved in P. gingivalis-induced oral dysbiosis and inflammation based on our previous observations and a robust body of literature that supports the antimicrobial and proinflammatory properties of PLA2-IIA as well as its role in other chronic inflammatory diseases.
Keywords
P. gingivalis; PLA2-IIA; Periodontal disease; Oral dysbiosis; Oral epithelial cells
Disciplines
Oral Biology and Oral Pathology
Language
English
Repository Citation
Gonzales, O. A.,
Euzebio-Alves, V.,
Alimova, Y.,
Al-Attar, A.,
Ebersole, J. L.
(2019).
A Potential Role of Phospholipase 2 Group IIA (PLA2-IIA) in P. gingivalis-Induced Oral Dysbiosis.
Advances in Experimental Medicine and Biology, 1197
79-95.
Cham, Switzerland: Springer Nature.
http://dx.doi.org/10.1007/978-3-030-28524-1_7