Document Type
Article
Publication Date
1-28-2020
Publication Title
Journal of Developmental Biology
Publisher
MDPI
Volume
8
Issue
2
First page number:
1
Last page number:
19
Abstract
Non-syndromic orofacial clefts encompass a range of morphological changes affecting the oral cavity and the craniofacial skeleton, of which the genetic and epigenetic etiologic factors remain largely unknown. The objective of this study is to explore the contribution of underlying dentofacial deformities (also known as skeletal malocclusions) in the craniofacial morphology of non-syndromic cleft lip and palate patients (nsCLP). For that purpose, geometric morphometric analysis was performed using full skull cone beam computed tomography (CBCT) images of patients with nsCLP (n = 30), normocephalic controls (n = 60), as well as to sex- and ethnicity- matched patients with an equivalent dentofacial deformity (n = 30). Our outcome measures were shape differences among the groups quantified via principal component analysis and associated principal component loadings, as well as mean shape differences quantified via a Procrustes distance among groups. According to our results, despite the shape differences among all three groups, the nsCLP group shares many morphological similarities in the maxilla and mandible with the dentofacial deformity group. Therefore, the dentoskeletal phenotype in nsCLP could be the result of the cleft and the coexisting dentofacial deformity and not simply the impact of the cleft.
Keywords
Non-Syndromic Cleft; Craniofacial Morphology; Midfacial Growth; Maxilla; Mandible; Malocclusion; Cephalometry; Computerized Tomography
Disciplines
Dentistry | Medicine and Health Sciences | Oral and Maxillofacial Surgery
File Format
File Size
808 KB
Language
English
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Liberton, D. K.,
Verma, P.,
Almpani, K.,
Fung, P. W.,
Mishra, R.,
Oberoi, S.,
Şenel, F. Ç.,
Mah, J. K.,
Huang, J.,
Padwa, B. L.,
Lee, J. S.
(2020).
Craniofacial Analysis May Indicate Co-Occurrence of Skeletal Malocclusions and Associated Risks in Development of Cleft Lip and Palate.
Journal of Developmental Biology, 8(2),
1-19.
MDPI.
http://dx.doi.org/10.3390/jdb8010002