Salivary Biomarkers for Discriminating Periodontitis in the Presence of Diabetes

Document Type

Article

Publication Date

10-23-2020

Publication Title

Journal of Clinical Periodontology

First page number:

1

Last page number:

10

Abstract

Aim: Salivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered in the presence of diabetes. Hence, the ability of salivary biomarkers to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined. Methods: Ninety‐two participants (29 with T2DM with chronic periodontitis, DWP; 32 T2DM without chronic periodontitis, DWoP; and 31 Not Periodontitis, NP) provided saliva and clinical parameters of periodontal health were recorded. Salivary concentrations of interleukin (IL)‐1β, IL‐6, matrix metalloproteinase‐8 (MMP‐8), macrophage inflammatory protein‐1α (MIP‐1α), adiponectin and resistin were measured by immunoassay. Results: Salivary analyte concentrations for IL‐1β, MMP‐8 and resistin correlated with clinical parameters of periodontitis, with MMP‐8 demonstrating the strongest positive correlation with... (See full abstract in article).

Keywords

Biological markers; Diabetes; Metalloproteases; Periodontitis; Saliva

Disciplines

Oral Biology and Oral Pathology

Language

English

UNLV article access

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