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Description
Blood-based biomarkers for neurodegenerative illnesses such as Alzheimer's disease (AD) have been extensively researched. Alzheimer's disease (AD) is a progressive neurological illness whose progression has been ascribed to gene expression. However, the pathophysiology of these disorders and its relationship to other abnormalities remain unknown. AD has been connected to PBCs, which include erythrocytes, platelets, and leukocytes and have a complicated interaction with the brain system. The pathogenesis of PBCs has been related to a negative influence on established neurodegenerative illnesses such as Alzheimer's. Candidate gene association studies have become more common as progress in mapping the human genome has increased their viability. The plurality of candidate genes were selected based on their function or expression in disease-related systems (e.g., dopamine neurotransmitter systems), and this strategy is crucial for defining the nature of internal disturbance. It has increasingly been postulated that, in addition to cell-cell signaling inside the brain, dynamic crosstalk between the brain and systematic mechanisms such as circulation of blood cells may be crucial.
Publication Date
Spring 4-27-2022
Language
English
Keywords
Alzheimer's disease; Neurosciences
Disciplines
Cognitive Science | Neuroscience and Neurobiology
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1675 KB
Recommended Citation
Cummings, Melika; Lu, Yimei; Cue, Joan Manuel; Patel, Neel; and Do, Jenifer, "Peripheral Blood Cell Counts as Potential Biomarkers for Alzheimer's Disease: A Look at Polygenetic Risk Scores" (2022). Undergraduate Research Symposium Posters. 116.
https://digitalscholarship.unlv.edu/durep_posters/116
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Comments
Faculty Mentor: Jingchun Chen