Characterization of USP7 substrates in the brain

Authors

Jose Itorralba, University of Nevada, Las VegasFollow
Sage Boss, University of Nevada, Las VegasFollow
Shahraiz Akbar, University of Nevada, Las Vegas
Hayley Baker, University of Nevada, Las Vegas
Chinglan Chang, University of Nevada, Las Vegas

Files

Description

Loss of function lesions in Ubiquitin-specific protease (USP) 7 are associated with intellectual disability, speech delay, autism spectrum disorder, and seizures. While the deubiquitinating activity of USP7 has been characterized in cancer, its role in neurological conditions is not understood. Here, we show that USP7 can regulate the development of the brain by localizing to synaptosomes in the hippocampus and stabilizing neural-specific substrates.

Publisher Location

Las Vegas (Nev.)

Publication Date

12-9-2022

Publisher

University of Nevada, Las Vegas

Language

English

Controlled Subject

Brain--Localization of functions

Disciplines

Neuroscience and Neurobiology

File Format

pdf

File Size

1000 KB

Comments

Faculty Mentors: Edwin C. Oh, Van Vo

Recommended Citation

Itorralba, Jose; Boss, Sage; Akbar, Shahraiz; Baker, Hayley; and Chang, Chinglan, "Characterization of USP7 substrates in the brain" (2022). Undergraduate Research Symposium Posters. 127.
https://digitalscholarship.unlv.edu/durep_posters/127

Rights

IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/