On a Microfabricated Ti-alloy-based Microneedle Array for Transdermal Drug Delivery

Authors

Wensheng Hou, Chongqing University
Biswajit Das, University of Nevada, Las VegasFollow
Yingtao Jiang, University of Nevada, Las VegasFollow
Shizhi Qian, Old Dominion UniversityFollow
Xiaolin Zheng, Chongqing UniversityFollow
J. Yang, Chongquing UniversityFollow
X. Pi, Chongqing UniversityFollow
H. Liu, Chongqing University
Jun Zheng, University of Nevada, Las VegasFollow
Yuheng Zheng, University of Nevada, Las Vegas

Document Type

Conference Proceeding

Publication Date

1-6-2008

Publication Title

Proceedings of the 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems

Publisher

IEEE

First page number:

453

Last page number:

456

Abstract

Transdermal drug delivery is a promising approach that allows controlled release of drug over time while avoiding possible degradation due to the gastrointestinal tract or first-pass liver effect. Of many different methods have been employed in transdermal drug delivery, microneedle is a widely explored MEMS-based device that can conveniently penetrate the skin and thus create micrometer-scale openings for drug absorption. In this paper, we attempt to study a Ti alloy-based microneedle array, particularly its fluidic features, through a series of simulations using ANSYS. The results indicate that, provided the volumetric flow rate is constant, the pressure of inlet decreases when the flow rate of inlet increases; the flow rate of outlet increases with the increase of pressure of inlet when flow rate of inlet is set to constant. In both scenarios, a complete description of liquid flow through microneedle conduit should consider in vivo effects such as the liquid absorption in the epidermis and the mechanic feature.

Keywords

Absorption; Degradation; Drug delivery; Epidermis; Fluid flow; Gastrointestinal tract; In vivo; Liver; Skin; Titanium alloys; Transdermal medication

Disciplines

Biomedical Devices and Instrumentation | Biomedical Engineering and Bioengineering | Medical Biotechnology

Language

English

Comments

Conference held: Sanya, 6-9 Jan. 2008

Permissions

Use Find in Your Library, contact the author, or interlibrary loan to garner a copy of the item. Publisher policy does not allow archiving the final published version. If a post-print (author's peer-reviewed manuscript) is allowed and available, or publisher policy changes, the item will be deposited.

Repository Citation

Hou, W., Das, B., Jiang, Y., Qian, S., Zheng, X., Yang, J., Pi, X., Liu, H., Zheng, J., Zheng, Y. (2008). On a Microfabricated Ti-alloy-based Microneedle Array for Transdermal Drug Delivery. Proceedings of the 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems 453-456. IEEE.