On a microfabricated ti-alloy-based microneedle array for transdermal drug delivery
Transdermal drug delivery is a promising approach that allows controlled release of drug over time while avoiding possible degradation due to the gastrointestinal tract or first-pass liver effect. Of many different methods have been employed in transdermal drug delivery, microneedle is a widely explored MEMS-based device that can conveniently penetrate the skin and thus create micrometer-scale openings for drug absorption. In this paper, we attempt to study a Ti alloy-based microneedle array, particularly its fluidic features, through a series of simulations using ANSYS. The results indicate that, provided the volumetric flow rate is constant, the pressure of inlet decreases when the flow rate of inlet increases; the flow rate of outlet increases with the increase of pressure of inlet when flow rate of inlet is set to constant. In both scenarios, a complete description of liquid flow through microneedle conduit should consider in vivo effects such as the liquid absorption in the epidermis and the mechanic feature.
Absorption; Degradation; Drug delivery; Epidermis; Fluid flow; Gastrointestinal tract; In vivo; Liver; Skin; Titanium alloys; Transdermal medication
Biomedical Devices and Instrumentation | Biomedical Engineering and Bioengineering | Medical Biotechnology
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On a microfabricated ti-alloy-based microneedle array for transdermal drug delivery.
Proceedings of the 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems