Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease

Authors

Ece Bayram, University of California San DiegoFollow
Sarah J. Banks, University of California San Diego
Guogen Shan, University of Nevada, Las VegasFollow
Nikki Kaplan, Lou Ruvo Center for Brain Health, Cleveland Clinic
Jessica Z.K. Caldwell, Lou Ruvo Center for Brain Health, Cleveland Clinic

Document Type

Article

Publication Date

12-11-2019

Publication Title

Journal of the International Neuropsychological Society

Publisher

Cambridge University Press

First page number:

1

Last page number:

9

Abstract

Objective: To evaluate the sex differences in cognitive course over 4 years in Parkinson’s disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. Methods: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson’s Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. Results: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). Conclusions: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.

Keywords

Parkinson’s disease; Cognition; Sex; Longitudinal studies; Memory; Decline

Disciplines

Psychiatric and Mental Health

File Format

pdf

File Size

287 KB

Language

English

Repository Citation

Bayram, E., Banks, S. J., Shan, G., Kaplan, N., Caldwell, J. Z. (2019). Sex Differences in Cognitive Changes in De Novo Parkinson’s Disease. Journal of the International Neuropsychological Society 1-9. Cambridge University Press.
http://dx.doi.org/10.1017/S1355617719001085