Document Type

Article

Publication Date

12-11-2019

Publication Title

Journal of the International Neuropsychological Society

Publisher

Cambridge University Press

First page number:

1

Last page number:

9

Abstract

Objective: To evaluate the sex differences in cognitive course over 4 years in Parkinson’s disease (PD) patients with and without mild cognitive impairment (MCI) compared to controls. Methods: Four-year longitudinal cognitive scores of 257 cognitively intact PD, 167 PD-MCI, and 140 controls from the Parkinson’s Progression Markers Initiative were included. Longitudinal scores of men and women, and PD with and without MCI were compared. Results: Women had better verbal memory, men had better visuospatial function. There was no interaction between sex, diagnostic group, and/or time (4-year follow-up period). Conclusions: Sex differences in cognitive course in de novo PD are similar to healthy aging. Cognitive decline rates in PD with and without MCI are similar for the first 4 years of PD.

Keywords

Parkinson’s disease; Cognition; Sex; Longitudinal studies; Memory; Decline

Disciplines

Psychiatric and Mental Health

File Format

pdf

File Size

287 KB

Language

English

Available for download on Friday, December 11, 2020

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