Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity

Authors

D Larson, University of Hawai‘iFollow
A Powers, University of Hawai‘i
J P. Ambrosi, Aix-Marseille Université
M Tanji, University of Hawai‘i
A Napolitano, University of Hawai‘i
E G. Flores, University of Hawai‘i
F Baumann, Université de la Nouvelle-Calédonie
L Pellegrini, University of Hawai‘i
C J. Jennings, University of Hawai‘i
Brenda Buck, University of Nevada, Las VegasFollow
B T. McLaurin, University of PennsylvaniaFollow
D Merkler, Natural Resources Conservation ServiceFollow
C Robinson, University of Western Australia
P Morris, University of Hawai‘i
M Dogan, Hacettepe University
A U. Dogan, University of Iowa
H I. Pass, New York Langone Medical CenterFollow
S Pastorino, University of Hawai‘i
M Carbone, University of Hawai‘iFollow
H Yang, University of Hawai‘iFollow

Document Type

Article

Publication Date

1-1-2016

Publication Title

Journal of Toxicology and Environmental Health - Part B: Critical Reviews

Volume

19

Issue

2017-05-06

First page number:

213

Last page number:

230

Abstract

Similar to asbestos fibers, nonregulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure to carcinogenic fibers was causing the development of MM. Palygorskite, a fibrous silicate mineral with a history of possible carcinogenicity, is abundant in southern Nevada. In this study, our aim was to determine whether palygorskite was contributing to the development of MM in southern Nevada. While palygorskite, in vitro, displayed some cytotoxicity toward primary human mesothelial (HM) cells and reduced their viability, the effects were roughly half of those observed when using similar amounts of crocidolite asbestos. No Balb/c (0/19) or MexTAg (0/18) mice injected with palygorskite developed MM, while 3/16 Balb/c and 13/14 MexTAg mice injected with crocidolite did. Lack of MM development was associated with a decreased acute inflammatory response, as injection of palygorskite resulted in lower percentages of macrophages (p =.006) and neutrophils (p =.02) in the peritoneal cavity 3 d after exposure compared to injection of crocidolite. Additionally, compared to mice injected with crocidolite, palygorskite-injected mice had lower percentages of M2 (tumor-promoting) macrophages (p =.008) in their peritoneal cavities when exposed to fiber for several weeks. Our study indicates that palygorskite found in the environment in southern Nevada does not cause MM in mice, seemingly because palygorskite, in vivo, fails to elicit inflammation that is associated with MM development. Therefore, palygorskite is not a likely contributor to the MM cases observed in southern Nevada. © , Published with license by Taylor & Francis Group, LLC © David Larson, Amy Powers, Jean-Paul Ambrosi, Mika Tanji, Andrea Napolitano, Erin G. Flores, Francine Baumann, Laura Pellegrini, Cormac J. Jennings, Brenda J. Buck, Brett T. McLaurin, Doug Merkler, Cleo Robinson, Paul Morris, Meral Dogan, A. Umran Dogan, Harvey I. Pass, Sandra Pastorino, Michele Carbone, and Haining Yang.

Language

English

Repository Citation

Larson, D., Powers, A., Ambrosi, J. P., Tanji, M., Napolitano, A., Flores, E. G., Baumann, F., Pellegrini, L., Jennings, C. J., Buck, B., McLaurin, B. T., Merkler, D., Robinson, C., Morris, P., Dogan, M., Dogan, A. U., Pass, H. I., Pastorino, S., Carbone, M., Yang, H. (2016). Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity. Journal of Toxicology and Environmental Health - Part B: Critical Reviews, 19(2017-05-06), 213-230.
http://dx.doi.org/10.1080/10937404.2016.1195321