Document Type
Article
Publication Date
7-9-2021
Publication Title
Scientific Reports
Volume
11
First page number:
1
Last page number:
11
Abstract
In type 2 diabetes, hyperuricemia is associated with cardiovascular disease (CVD) and the metabolic syndrome (MetS), but associations in type 1 diabetes (T1D) have not been well-defined. This study examined the relationships between serum urate (SU) concentrations, clinical and biochemical factors, and subsequent cardiovascular events in a well-characterized cohort of adults with T1D. In 973 participants with T1D in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study (DCCT/EDIC), associations were defined between SU, measured once in blood collected 1997-2000, and (a) concurrent MetS and (b) incident 'any CVD' and major adverse cardiovascular events (MACE) through 2013. SU was higher in men than women [mean (SD): 4.47 (0.99) vs. 3.39 (0.97) mg/dl, respectively, p < 0.0001], and was associated with MetS features in both (men: p = 0.0016; women: p < 0.0001). During follow-up, 110 participants (11%) experienced "any CVD", and 53 (5%) a MACE. Analyzed by quartiles, SU was not associated with subsequent CVD or MACE. In women, SU as a continuous variable was associated with MACE (unadjusted HR: 1.52; 95% CI 1.07-2.16; p = 0.0211) even after adjustment for age and HbA1c (HR: 1.47; 95% CI 1.01-2.14; p = 0.0467). Predominantly normal range serum urate concentrations in T1D were higher in men than women and were associated with features of the MetS. In some analyses of women only, SU was associated with subsequent MACE. Routine measurement of SU to assess cardiovascular risk in T1D is not merited.Trial registration clinicaltrials.gov NCT00360815 and NCT00360893.
Keywords
Serum urate; Cardiovascular disease; Epidemiology of diabetes; Type 2 diabetes
Disciplines
Endocrinology, Diabetes, and Metabolism | Medical Specialties | Medicine and Health Sciences
File Format
File Size
1131 KB
Language
English
Rights
IN COPYRIGHT. For more information about this rights statement, please visit http://rightsstatements.org/vocab/InC/1.0/
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Repository Citation
Jenkins, A. J.,
Braffett, B. H.,
Basu, A.,
Bebu, I.,
Dagogo-Jack, S.,
Orchard, T. J.,
Wallia, A.,
Lopes-Virella, M. F.,
Garvey, W.,
Lachin, J. M.,
Lyons, T. J.
(2021).
Serum Urate and Cardiovascular Events in the DCCT/EDIC Study.
Scientific Reports, 11
1-11.
http://dx.doi.org/10.1038/s41598-021-90785-4