Exosomal Microrna Differential Expression in Plasma of Young Adults With Chronic Mild Traumatic Brain Injury and Healthy Control

Document Type

Article

Publication Date

1-1-2022

Publication Title

Biomedicines

Volume

10

Issue

1

Abstract

Chronic mild traumatic brain injury (mTBI) has long-term consequences, such as neurological disability, but its pathophysiological mechanism is unknown. Exosomal microRNAs (exo-miRNAs) may be important mediators of molecular and cellular changes involved in persistent symptoms after mTBI. We profiled exosomal microRNAs (exomiRNAs) in plasma from young adults with or without a chronic mTBI to decipher the underlying mechanisms of its long-lasting symptoms after mTBI. We identified 25 significantly dysregulated exomiRNAs in the chronic mTBI group (n = 29, with 4.48 mean years since the last injury) compared to controls (n = 11). These miR-NAs are associated with pathways of neurological disease, organismal injury and abnormalities, and psychological disease. Dysregulation of these plasma exomiRNAs in chronic mTBI may indi-cate that neuronal inflammation can last long after the injury and result in enduring and persistent post-injury symptoms. These findings are useful for diagnosing and treating chronic mTBIs.

Keywords

ExomiRNA; Exosome; MicroRNA; Mild traumatic brain injury

Disciplines

Cell Biology | Molecular Biology

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