Mild Acute Inflammation does not Impair Maintenance of Blood Pressure during a Hypotensive Stimulus

Document Type

Article

Publication Date

5-25-2020

Publication Title

Artery Research

Volume

26

Issue

3

First page number:

180

Last page number:

182

Abstract

Severe acute inflammation, such as sepsis, disrupts autonomic nervous system function and jeopardizes blood pressure regulation [1]. Acute hypotension under normal conditions stimulates baroreceptors to restore blood pressure by activating the sympathetic nervous system to increase heart rate and vasoconstrict peripheral vasculature. Severe acute experimental inflammation (endotoxin) blunts baroreflex-mediated increases in muscle sympathetic nerve activity during reductions in blood pressure and uncouples baroreflex control of heart rate [2]. Whether mild acute inflammation alters the ability to maintain blood pressure during a hypotensive challenge is less clear.

Keywords

Acute inflammation; Blood pressure; Blood flow; LBNP

Disciplines

Cardiovascular Diseases | Diseases | Medicine and Health Sciences

Language

English

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