Altered Central Hemodynamics in Individuals with Down Syndrome
Document Type
Article
Publication Date
12-24-2019
Publication Title
Artery Research
Volume
25
Issue
3
First page number:
107
Last page number:
112
Abstract
Background: Individuals with Down Syndrome (DS) have autonomic dysfunction impacting regulation of heart rate, Blood Pressure (BP), and peripheral vasoconstriction. This may alter central hemodynamics through different wave reflections. We investigated central hemodynamics including wave reflection during rest and a sympathoexcitatory stimulus [Lower Body Negative Pressure (LBNP)] in individuals with DS and controls. Methods: Radial applanation tonometry was performed on participants with and without DS before and during 5-min LBNP stimulus of −20 mmHg. Waveforms were calibrated to mean and diastolic BP. Generalized transfer function was used to estimate aortic pressures [Systolic Blood Pressure (aSBP), Diastolic Blood Pressure (aDBP), mean pressure (aMAP), pulse pressure (aPP)], Augmentation Index (AIx), augmentation index normalized for HR (AIx@75), Augmentation Pressure (AP), Reflection Index (RIx), Time to Reflection (Tr), forward and reflected wave magnitude (Pf and Pb). Results: Fifteen individuals with DS (male n = 12, age 24 ± 4 years, BMI 28 ± 5 kg/m2) and 16 control participants (male n = 12, age 24 ± 4 years, BMI 25 ± 5 kg/m2) participated. Baseline differences showed greater AP, higher AIx and AIx@75, a greater RIx, shorter Tr and larger Pb in individuals with DS (p...). (See full abstract in article).
Keywords
Down syndrome; Vascular function; Sympathetic stimulus; Autonomic nervous system
Disciplines
Circulatory and Respiratory Physiology | Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Language
English
Repository Citation
Hilgenkamp, T. I.,
Schroeder, E. C.,
Wee, S. O.,
Grigoriadis, G.,
Rosenberg, A. J.,
Baynard, T.,
Fernhall, B.
(2019).
Altered Central Hemodynamics in Individuals with Down Syndrome.
Artery Research, 25(3),
107-112.
http://dx.doi.org/10.2991/artres.k.191204.001