Criteria for Psychosis in Major and Mild Neurocognitive Disorders: International Psychogeriatric Association (IPA) Consensus Clinical and Research Definition
Document Type
Article
Publication Date
12-1-2020
Publication Title
American Journal of Geriatric Psychiatry
Volume
28
Issue
12
First page number:
1256
Last page number:
1269
Abstract
Psychosis is common among individuals with neurocognitive disorders, is diffi- cult to manage, and causes considerable burden and stress to patients and care- givers. Developing effective treatments is a substantial unmet medical need but research has been slowed by the need for updated consensus diagnostic criteria. To address this need, the International Psychogeriatrics Association initiated a process to develop criteria for clinical use, research, and treatment development efforts. The process included clinical, regulatory, and industry stakeholders as well as input from a global network of experts in geriatric psychiatry respond- ing to two surveys (N = 336). Results from the consensus process confirmed that clinicians wanted elaboration of aspects of the definition proposed by Jeste and Finkel in 2000 to ensure that the criteria are applied appropriately. Based on discussions, the survey, and emerging research, criteria were revised to apply to psychosis occurring with all major and mild neurocognitive disorders. Other important changes include providing examples of hallucinations and delusions and clarifying time course, impact, and exclusionary criteria. This definition of psychosis in major and mild neurocognitive disorders can be used to advance many types of research including development of much needed pharmacologic and nonpharmacologic interventions for psychosis in patients with neurocogni- tive disorders. (Am J Geriatr Psychiatry 2020; 28:1256−1269)
Keywords
Alzheimer’s disease; Psychosis; Major neurocognitive disorder; Mild neurocognitive disorder; Hallucinations; Delusions; Diagnoses; Therapy; Development; Clinical trials
Disciplines
Cognitive Neuroscience | Mental Disorders
Language
English
Repository Citation
Cummings, J.,
Cortez Pinto, L.,
Cruz, M.,
Fischer, C. E.,
Gerritsen, D. L.,
Grossberg, G. T.,
Hwang, T.,
Ismail, Z.,
Jeste, D. V.,
Koopmans, R.,
Lanctot, K. L.,
Mateos, R.,
Peschin, S.,
Sampaio, C.,
Tsuang, D.,
Wang, H.,
Zhong, K.,
Bain, L. J.,
Sano, M.
(2020).
Criteria for Psychosis in Major and Mild Neurocognitive Disorders: International Psychogeriatric Association (IPA) Consensus Clinical and Research Definition.
American Journal of Geriatric Psychiatry, 28(12),
1256-1269.
http://dx.doi.org/10.1016/j.jagp.2020.09.002