The Future of Anti-Amyloid Trials

Document Type

Article

Publication Date

3-1-2020

Publication Title

Journal of Prevention of Alzheimer's Disease

Volume

7

Issue

3

First page number:

146

Last page number:

151

Abstract

© 2020, The Author(s). The termination of many clinical trials of amyloid-targeting therapies for the treatment of Alzheimer’s disease (AD) has had a major impact on the AD clinical research enterprise. However, positive signals in recent studies have reinvigorated support for the amyloid hypothesis and amyloid-targeting strategies. In December 2019, the EU-US Clinical Trials on Alzheimer’s Disease (CTAD) Task Force met to share learnings from these studies in order to inform future trials and promote the development of effective AD treatments. Critical factors that have emerged in studies of anti-amyloid monoclonal antibody therapies include developing a better understanding of the specific amyloid species targeted by different antibodies, advancing our insight into the mechanism by which those antibodies may reduce pathology, implementing more comprehensive repertoires of biomarkers into trials, and identifying appropriate doses. Studies suggest that Amyloid-Related Imaging Abnormalities — effusion type (ARIA-E) are a manageable safety concern and that caution should be exercised before terminating studies based on interim analyses. The Task Force concluded that opportunities for developing effective treatments include developing new biomarkers, intervening in early stages of disease, and use of combination therapies.

Keywords

Alzheimer’s disease; Amyloid hypothesis; BACE inhibitors; Combination therapy; Dementia; Monoclonal antibody treatment

Disciplines

Cognitive Neuroscience

Language

English

UNLV article access

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