Document Type

Article

Publication Date

5-31-2023

Publication Title

BMJ Open

Publisher

BMJ

Volume

13

Issue

5

First page number:

1

Last page number:

3

Abstract

Introduction: Remdesivir is an antiviral medication that is used in the treatment of severe COVID-19. Research has highlighted the potential cardiac side effects of remdesivir, including the occurrence of remdesivir-associated bradycardia (RAB), but these findings have not been consistent. In addition, very little is known about the clinical implications and outcomes of RAB. The aim of this rapid systematic review is to determine the event rate of developing bradycardia while receiving remdesivir treatment compared with not receiving remdesivir in patients diagnosed with COVID-19.

Methods and analysis: This study follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol guidelines and will include original papers related to COVID-19, remdesivir and bradycardia. Only English language papers published from 1 December 2019 to 31 December 2022 will be included. The following databases will be searched using keywords and controlled vocabulary: Ovid MEDLINE, Ovid EMBASE, Scopus, Cochrane, PubMed and Web of Science. Two reviewers will independently perform screening and data abstraction. Data will be synthesised qualitatively as well as quantitatively. A random-effects model will be used to calculate the pooled estimates.

Ethics and dissemination: This review will systematically analyse the clinical studies available to help better characterise RAB. The results will support a retrospective study investigating RAB that is currently being conducted at the University Medical Center of Southern Nevada in Las Vegas, Nevada.

Controlled Subject

COVID-19 (Disease)--Prevention

Disciplines

Medical Sciences

File Format

pdf

File Size

227 KB

Language

English

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

Publisher Citation

Tian E, Cosme C, Bauzon J, et al. Remdesivir-associated bradycardia in COVID-19: a rapid review protocol. BMJ Open 2023;13:e068564. doi:10.1136/bmjopen-2022-068564

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